Dendrosomal Curcumin Inhibits Metastatic Potential of SW480 Colon Cancer Cells

Colorectal cancer (CRCs) is the third most common cancer in men and the second in women (Ferlay et al., 2008; Ku et al., 2012). Generally, the lowest incidence rates among both men and women are reported in Africa, Central and South America, and South Central Asia (India and Pakistan) (Ferlay et al., 2008; Ku et al., 2012). The prognosis for advanced CRCs remains dismal, mainly due to the propensity for metastatic progression (Gulhati et al., 2011). In the initial step of cancer metastasis, tumor cells sometimes undergo epithelial-mesenchymal transition (EMT), which requires the disruption of cell-cell adhesions (Hynes, 2002; Meng and Takeichi, 2009). In many cases, metastasis may occur as a result of dysregulation in cell adhesions molecules or signaling cascades proteins involved in cell adhesion such as Hef 1 (Li et al., 2011), Zeb 1 (Amar et al., 2011) and Claudin 1(Cld 1) (Nobutomo et al., 2001), that in previous study, were suggested to be associated with cellular migration in colon cancer. Accordingly, there is a need for nontoxic therapeutic agents which are easy and effective to use for cancer prevention and treatment. About 80% of all anticancer drugs today are somehow composed from